![]() ![]() Drugs such as dexchlorpheniramine and alimemazine (trimeprazine) were not found to have any teratogenic effect even in animal studies. Certain animal studies with hydroxyzine, cyclizine, and promethazine have shown teratogenic effects, but no human teratogenicity reports have so far been reported. Various studies on the use of antihistamines (H 1 blockers) during pregnancy, including a meta-analysis of more than 200,000 women shows no increase in the teratogenic risk of these drugs in the humans. Many a times the patient procures these agents as an over the counter preparation and uses it. The physician has to weigh the benefits of the treatment against the potential teratogenic effects before using any drug during pregnancy.Īmong the drugs prescribed during pregnancy, antihistamines are one of the commonest, either as an antipruritic agent or an antiemetic agent. All pharmacological interventions are generally avoided during pregnancy due to the alarming information present in the patient information leaflet and also on the drug envelopes. Drugs taken during the pregnancy can also lead to after effects in the neonatal and infancy period. If a drug is consumed during the first trimester, it can result in severe structural fetal malformations and in the later part of pregnancy it can result in various functional defects or growth disorders and can also lead to minor malformations. Allergies can occur in about 20–30% of women during pregnancy.Īny drug taken during the pregnancy has a potential teratogenic effect on the fetus. Other than itching antihistamines are also used for various allergic diseases and also used for emesis during pregnancy. In addition to these, various systemic diseases can also manifest with pruritus. ![]() Causes for pruritus in pregnancy are numerous ranging from specific dermatoses of pregnancy to various dermatological conditions such as atopic dermatitis, urticarial, infections, and infestations or drug induced. Pruritus occurs due to various causes, and it can occur any time during pregnancy. Pruritus in pregnancy has always been challenging to the treating physician both in diagnosis and treatment. Pruritus is one of the most common dermatological symptoms in pregnancy. ![]()
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